The 9 Best NAD+ Serums of 2026

NAD+ started in supplements before it moved into skincare. Now you’ll find it in serums too, with the same promises of cellular energy, DNA repair, and younger-looking skin.

NAD+ stands for nicotinamide adenine dinucleotide, a coenzyme your body makes naturally to fuel that energy and repair. Levels decline as you age, which is why the ingredient found its way into skincare.

But taking NAD+ and applying it are not the same thing, and not every NAD+ serum backs up its claim. To find out which do, we looked at the formulation and supporting ingredients behind 9 of the most searched NAD+ serums on the market.

If you want the full science, read our breakdown on what NAD+ is and how it behaves in skin. And if you’re curious how NAD+ compares with niacinamide, we’ve covered that comparison too.

How to Choose an NAD+ Serum

NAD+ is a large molecule, and it’s highly unstable, so check for these 3 things before you buy.

1. Check the ingredient list. Look for niacinamide, NMN, NR, or NAD+ itself, which appears on ingredient labels as Nicotinamide Adenine Dinucleotide, then check where it sits on the list. If it’s higher up on the list, it’s there in an amount that could do something. But if it’s buried down the list, it’s probably not there in an amount that backs up the claim.

2. Check the packaging. NAD+ breaks down under light and air, so opaque, airless packaging protects it far better than a clear bottle you pour from.

3. Check for a delivery system. If a brand uses NAD+ directly, look for any mention of encapsulation or a stabilized delivery method. That is a better sign than a plain, unencapsulated formula.

The 9 serums below hold up like this.

1. Best NAD+ Serum Overall: Pai Age Confidence Renewal Serum with NAD+ and TriPeptide

Pai’s ingredient list doesn’t include NAD+ or any of its precursors. The formula uses Sunflower Sprout Extract to stimulate NAMPT, the enzyme your skin already uses to make its own NAD+. This solves the delivery problem our pharmacologist flagged at the start of this roundup, since NAD+ is too large and unstable to cross the skin barrier on its own.

The formula also contains a Tripeptide Complex, Centella Asiatica, and hyaluronic acid, which support collagen production and help repair the skin barrier. It layers well with retinol and vitamin C. It’s fragrance-free, patch tested for sensitive skin, and comes in a pump bottle with an inner pouch, keeping the formula intact.

Beyond that, this is the only product here with published human data behind it, though Pai funded the study itself, meaning the results may carry some bias. The study reported statistically significant firming and wrinkle reduction within 4 weeks, and by 8 weeks measured a 9.45% drop in wrinkle depth, 11% more firmness, and 17.95% better hydration, across 21 subjects.

2. Best NAD+ Serum for Face and Body: numbuzin No.9 NAD Bio Lifting-Sil Essence

This lightweight serum combines NAD+ with 50 different peptides. The brand describes it as firming skin and improving texture. It can be used in the morning or at night before applying moisturizer, on your face and body.

NAD+ is in the formula, but it sits far down the ingredient list, well behind niacinamide and adenosine. Niacinamide supports your skin’s own NAD+ production, adenosine helps smooth the look of fine lines, and the 50 peptides target firmness, so all 3 are doing more of the real work than the NAD+ itself.

It’s fragrance-free and comes in an airless pump to keep the ingredients intact.

3. Best NAD+ Serum Mist: haruharu wonder Black Rice Probiotics Barrier 2% NAD+ Serum Mist

This ultra-fine mist is formulated with NAD+ at a claimed 2%, alongside a 5-ceramide complex, black rice extract, and probiotic ferments, for hydration, plumping, and a glass-skin glow. NAD+ sits near the top of the ingredient list, the strongest position of any product in this roundup. Over 14 days, Haruharu’s own in-house testing found a 32.12% improvement in moisture, a 16.66% stronger barrier, and a 12.20% gain in elasticity. But a formula this rich in ceramides, ferments, and squalane would likely produce similar results on its own, so the improvement can’t be credited to the NAD+ specifically. Spray it throughout the day over makeup or bare skin, or use it as the hydrating step in a full routine.

It’s fragrance-free, vegan, and comes in an opaque spray bottle with a fine-mist nozzle that protects the formula from light and air.

4. Best Budget NAD+ Serum: EQQUALBERRY NAD+ Peptide Boosting Serum

This serum combines NAD+ with 14 peptides, 5 ceramides, and vegan collagen, along with antioxidant-rich fruit extracts like pomegranate. The brand describes it as firming skin and restoring elasticity. Apply after toning and pat gently to help it absorb, morning or night.

NAD+ is in the formula, and it actually sits ahead of adenosine and NMN on the ingredient list. But niacinamide comes before all 3, which means it’s likely still doing more of the real work in this formula than the NAD+ itself.

It’s fragrance-free and comes in a glass bottle with a dropper.

5. Best NAD+ and EGF Combined Serum: medicube NAD EGF Firming Serum

This serum pairs NAD+ with EGF, or epidermal growth factor, and collagen, targeting fine lines, firmness, elasticity, and pore appearance. Apply 2 to 3 drops after toning, pat to help it absorb, and follow with moisturizer, morning and evening.

NAD+ is in the formula, but on the ingredient list it comes after niacinamide, adenosine, and EGF. NAD+ is disclosed at a small, precise concentration, though niacinamide is likely still doing more of the real work given its earlier position. The brand states the product was clinically tested by a named research institute, but the only disclosed result is smoother looking skin after 2 weeks, with no specific percentage given.

It’s non-comedogenic and dermatologist tested for skin irritation, and dispensed in drops.

6. Best NMN Ampoule for Firming: MAKE P:REM NMN NAD+ Firming Expert Ampoule Serum

This ampoule is built around NMN at a claimed 10,000ppm, backed by a 5-peptide firming system and resveratrol. The brand says it visibly firms, smooths, and improves elasticity. Apply after cleansing and toning, morning or night, and follow with moisturizer.

NAD+ also appears on the label, but it sits much further down the ingredient list than the NMN does. Its concentration isn’t disclosed, unlike the NMN’s.

It comes in a dropper.

7. Best NAD+ and NMN Combined Serum: Obagi NU-GEN NAD+ Cellular Renewal Face Serum

This serum is built around Obagi’s AGE CTRL Complex, combining NAD+, NMN, and niacinamide with sodium hyaluronate, beta-glucan, and sunflower sprout extract. The brand claims it visibly rewinds skin’s age by up to 6 years, based on studies described only as data on file with Obagi. Apply 2 to 3 pumps morning and evening after cleansing.

Both NAD+ and NMN land within the first half of a short, 28-ingredient list, though Obagi doesn’t disclose a specific concentration for either one.

It comes in a pump and is fragrance-free.

8. Best NMN Serum for Glow: Siore NMN Intensive Serum

This serum is built around 99% purity NMN at a disclosed 10,000ppm, alongside salmon PDRN, pycnogenol, and alpha lipoic acid. The brand positions it to plump, firm, and add glow to skin. Dispense 1 to 2 pumps after toner and massage in.

It comes in a pump bottle.

9. Best Minimal-Ingredient NAD+ Serum: Young Goose Youth Reset V2 Pro-Youth Serum

This serum is built around what the brand calls NAD+ precursor nano-particles, alongside spermidine, peptides, vitamin C, and resveratrol. The brand says it targets all 12 recognized hallmarks of aging. Apply before bed and follow with moisturizer.

At 30 ingredients, shorter than most of this roundup, the peptides, vitamin C, and hyaluronic acid all sit near the top of the list. NAD+ itself sits near the bottom.

Do You Actually Need an NAD+ Serum?

For most people, not yet. NAD+ is well established as an oral supplement, but it’s new to skincare, and research on its topical benefits remains thin. If that novelty still appeals to you, an NAD+ serum is a reasonable thing to try.

If you want ingredients with a strong research record behind them, retinoids, niacinamide, and daily sunscreen belong in an anti-aging routine. Across nearly every serum in this roundup that lists both ingredients, niacinamide sits higher on the label than NAD+ itself, suggesting niacinamide is doing more of the real work in this category than the trend ingredient it’s paired with. Niacinamide also helps your skin make its own NAD+, so it’s worth reading our Best Niacinamide Serums roundup and NAD+ vs Niacinamide comparison before you decide.

How to Use an NAD+ Serum

Apply to clean skin, morning or night, and follow with sunscreen if it’s your morning step. NAD+ layers the same way niacinamide does, so our full guide on how to use NAD+ in your routine covers the details on combining it with retinol, vitamin C, and AHAs.